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Luteinized Adult Granulosa Cell Tumor F /70 (19904) » HE 20x 4.jpg
Filename: HE 20x 4.jpg
[Luteinized Adult Granulosa Cell Tumor F /70]
Female 70 years old, with tumours in both ovaries (hysterectomia with bilateral adnexectomia was made).  
MACRO: Greyish, brown with rough surface tumour occupying whole ovary, forming 7cm - in one and ~14 cm mass in another ovary.  
MICRO: various size confluent nodules and diffuse areas of large polygonal, clear cell outlines cells with abundant eosinophilic cytoplasm and round nucleus and alternating zones of smaller spindle-shaped cells. Zonal higher cells polymorphism, necrosis and haemorrhages. There are small groups of smaller eosinofilic monomorphic cells around some nodules. Few high-power fields with 1-2 mitoses.  
IMUNO: Tumour: WT1 (+) 100%, Calretinin (+)~40%, Inhibin (+)~10%, Ki67 (+) 2-3%, ER (++/+++), Hepa (+) single cells. Inhibin ir Calretinin (+)smaller eosinophilic cells.  
 
AFP/CD117/Synaptophysin/ChromograninA/AsmActin/Desmin/MelanA/HMB45/CD10/Cam5.2/PANCK/CK7/CK20/S100 (-).  
Proposal diagnosis: Sex cord-stromal tumour: Leydig cell tumour? Steroid cell tumour?  
Sender: Indra
2010-03-25 17:28
INCTR - Lithuanian Pathology online

Last modified: 2010-03-25 17:28:10