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Aspirate LT: quality control 1 (6526) » Hypersegmented 60x 1
Filename: Hypersegmented 60x 1
[Aspirate LT: quality control 1]
55 yrs male with threpine biopsy and aspirate.  
Diagnosis: aplastic anemia.  
History: 1 day patient from foreign country is under evaluation for BM transplant.  
Threpine hypocellular with fibrosis, arhitectural distortion, lymphoid agregattes and Fe deposition (MDS like picture). Only single micromegakaryocytes. Scattered NASDE+ granulopoietic cells, single erythroid cells, multiple eosinophils, maybe mastocytes are present. Some NASDE(-) precursor cells with "blastic" morphology. Blood test is attached.  
Smear: Photos are made with standard 60x lens. In case I have 100x oil in reserve:) An aspirate seems to be low cellular, foccaly overcrowded by erythrocytes.  
 
IH (hot spots): CD34/CD117+ precursors with slight clustering up to 20%; CD117+ mastocytes; Lymphos: CD3+ >> CD20+ (single); Single CD138+ plasmacytes; CD34+ neovascularity is prominent. vWF+ single micromegakaryocytes.  
 
WORKING: Architectural distortion with excess CD34+/CD17+ precursors up to 20% (scant hematopoietic population at all), III-IV fibrosis and prominent Fe deposition: high grade MDS is suspected. The use of CSF must be excluded.  
 
Please comment all diagnostic things, especially techno aspects and cytology.  
Thank you a lot.
Sender: ugnius
2008-11-06 09:41
INCTR - Hematopathology teaching group

Last modified: 2008-11-06 09:41:35